Villa Astalli was built in the 17th century in an area, the lower Esquiline, free of other buildings. We do not know if the villa already existed at the time of Cardinal Astalli, one of the most important members of the family, who regained prestige, after a period of economic decline, with his appointment as cardinal by Innocent X and his adoption into the Pamphilj family, whose name he was allowed to bear.
Of the original construction today only the building belonging to the Daughters of Our Lady of Calvary remains. The façade of the building preserves the original decoration with stucco plaques on the windows and busts in ovals.
Inside, in the main hall, there is a fine frieze with fantastic landscapes (also found in the three rooms to the north-west) and the four coats of arms of the Astalli in the corners. A wing of the building also houses a valuable chapel built in modern times.
Only a few remains of the ancient garden survive, including a simple fountain now located in the garden in front of the side façade of the building.
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