The building is known as the house of Sixtus V because it was inhabited by the pope's great-granddaughter, Flavia Peretti, wife of Virginio Orsini, Duke of Bracciano, who had the palace embellished for her wedding.
The interior features decorated rooms, including the vestibule with grotesques and, on the main floor, the loggia decorated by Cavalier d'Arpino and the hanging garden.
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